Without litigating terminology it is true that there are not like single receptor effects, or that there is a potentially fatal rebound. However it does mess with homeostasis in ways that can make it difficult to stop. Sudden cessation can cause difficult sleeping, anxiety, nightmares, appetite suppression, restlessness, and low mood. It’s relatively easy to deal with compared to stuff that messes with gaba, opiod receptors, or dopamine but it’s still much harder than changing what you eat or whatever.

Review from Canadia finds: https://scholar.google.com/scholar?as_ylo=2020&q=cannabis+health++review&hl=en&as_sdt=0,5&as_rr=1#d=gs_qabs&t=1731272057908&u=%23p%3DZQNk8wwxTvkJ

Legalization has been associated with increased adult hospital attendances for psychiatric distress and vomiting, unintentional ingestion of edible cannabis products by children and hospitalizations for cannabis use disorders in adults. There is conflicting evidence on whether cannabis‐impaired driving has increased since legalization. There is suggestive evidence that presentations to emergency departments with psychoses and cannabis use disorders may have increased since legalization.

Evidence of slight increases in psychosis, consistent with hypothesis that cannabis can trigger episodes in people with pre-existing conditions. Evidence that taking too much is uncomfortable.

https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(22)00161-4/abstract

finds that strong cannabis might make mental health worse.

Realistically inhaling it is the most harmful thing if you’re not prone to bad brain.

People have used it for a long time without serious harm but the higher dose modern strains are increasingly associated with stuff like hyperemises syndrome. So uh as with all things enjoy in moderation, we are all but food for worms, it’s probably safer than driving a car or whatever.